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" /> Servicio Farmacia Hospital General Universitario de Alicante
CONTACTO ALTA USUARIOS ACCESO RESTRINGIDO

Estabilidades Mezclas Intravenosas


COMPATIBILIDAD DE MEDICAMENTOS EN MEZCLAS INTRAVENOSAS


La preparación de mezclas de medicamentos para su administración intravenosa puede presentar problemas por la aparición de cambios fisicoquímicos que pueden comprometer la estabilidad de la mezcla.

Tradicionalmente, la incompatibilidad de mezclas ha sido clasificada como incompatibilidad física (aparición de cambios visuales como precipitación o cambio de color) o incompatibilidad química (reacciones directas entre los medicamentos que no son aparentes visualmente al ojo humano).

Una mezcla se considera estable mientras la concentración de los componentes se mantenga por encima del 90% de la inicial durante el periodo de validez de la preparación.

La decisión de preparar o no una determinada combinación de medicamentos está sujeta a la situación clínica del paciente, y debe ser tomada según la concentración de los fármacos, el disolvente, el tipo de contenedor y las condiciones de conservación, con el fin de asegurar la estabilidad física y química de la mezcla.

Por este motivo, y puesto que la incompatibilidad de mezclas no siempre es aparente visualmente, el profesional que prepara estas mezclas debe consultar la información disponible en el HGUA sobre compatibilidad de medicamentos antes de sla administración al paciente.

El objetivo fundamental de esta sección informativa es presentar, por un lado, y de forma sencilla una lista de compatibilidad entre medicamentos de uso frecuente que facilite la labor de la persona que prepara estos tratamientos.

La tabla de compatibilidades estará disponible en formato póster en todas las áreas de preparación de medicamentos en mezclas intravenosas del HGUA.


Queremos advertir que la información recogida en esta tabla es un resumen de los contenidos de la iGFT, que puede visitar en intranet-GFT


OTRAS FUENTES ONLINE: STABILIS

La asociación francesa INFOSTAB publica una base de datos internacional sobre estabilidad y compatibilidad de fármacos inyectables, STABILIS, traducida a 24 idiomas. Actualmente, la página Web se centra principalmente en aspectos relacionados con la estabilidad y compatibilidad de fármacos inyectables y contiene información actualizada, publicaciones y posters, así como enlaces con diversos estudios de estabilidad, con otras bases de datos y con revistas que contienen publicaciones sobre el tema.


Título Fecha Descargar
         
  TABLA DE COMPATIBILIDAD  
  Tabla de compatibilidad de medicamentos en mezclas intravenosas  (Copia de Libro1(1).2-COMPATIBILIDADES.xls) 168,00Kb. 21/10/2010  
   
  NOTAS INFORMATIVAS  
  Compatibilidad físico-química mezcla aciclovir sódico y amikacina sulfato  Factores asociados a la preparación que influyen en la estabilidad de la mezcla iv (Amikacina_aciclovir_ compatibilidad IV2.doc) 231,00Kb. 12/01/2011  
   
         
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